ABSTRACT
BACKGROUND: Topical photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA) was originally used for treating superficial skin tumors. The application of PDT to other inflammatory dermatoses like acne vulgaris, psoriasis, granuloma annulare, localized scleroderma and lichen sclerosus has recently been introduced. However, the underlying mechanisms are not well understood. We've previously reported the induction of tumor growth factor (TGF)-beta1 and interleukin (IL)-10 after PDT with ALA and intense pulsed light (IPL) in cultured HaCaT cells. OBJECTIVE: The purpose of this study was to investigate the expressions of TGF-beta1 and IL-10 in cultured fibroblasts after PDT with using ALA and IPL. METHODS: Cultured fibroblasts were treated with ALA-IPL PDT (1micromol/L of ALA; 0, 4, 8 and 12 J/cm2 of IPL). The expressions of TGF-beta1 and IL-10 were investigated by reverse transcription-polymerase chain reaction and enzyme linked immunosorbent assay. RESULTS: TGF-beta1 mRNA and protein were reduced down to 0.52- and 0.63-fold, respectively, after PDT and the IL-10 protein was increased up to 2.74-fold after PDT. CONCLUSION: The reduction of TGF-beta1 was prominent after PDT and so an antisclerotic effect can be expected after PDT. The induction of IL-10 may contribute to the anti-inflammatory effect, which explains the therapeutic benefit of PDT for inflammatory dermatoses.
Subject(s)
Acne Vulgaris , Aminolevulinic Acid , Fibroblasts , Granuloma Annulare , Interleukin-10 , Interleukins , Lichen Sclerosus et Atrophicus , Light , Photochemotherapy , Psoriasis , RNA, Messenger , Scleroderma, Localized , Skin , Skin Diseases , Transforming Growth Factor beta1 , TriazenesABSTRACT
We report here on a 63-year-old woman who presented with recurrent bruise-like infiltrative plaques on the left leg without systemic symptoms or laboratory abnormalities. The histopathologic findings showed an infiltration of panniculus by small to medium-sized atypical lymphocytes. But the prominent lymphoid atypia, fat necrosis, vascular thrombosis, erythrophagocytosis and striking dominance of CD8+ lymphocytes seen in subcutaneous panniculitis-like T-cell lymphoma (SPTCL) were not detected. The diagnosis of atypical lymphocytic lobular panniculitis (ALLP) was made based on these histopathologic and clinical features. The lesions responded well to systemic steroid treatment. But the CD4/CD8 ratio in the later lesion was more decreased than that of the initial lesion, and the patient is under clinical follow up.
Subject(s)
Female , Humans , Middle Aged , Fat Necrosis , Follow-Up Studies , Leg , Lymphocytes , Lymphoma, T-Cell , Panniculitis , Strikes, Employee , ThrombosisABSTRACT
Anterior cervical hypertrichosis (ACH) refers to a patch of hair that is presented at the lower anterior aspect of the neck just above the sternal notch along the cervical midline. The condition occurs as an isolated defect or in association with other abnormalities. Eighteen out of the 28 ACH patients who were previously reported on in the English literature showed a familial inheritance pattern. Some of the reported cases were associated with other clinical symptoms such as peripheral sensory and motor neuropathy, developmental delay, retinal change and bony abnormality. Herein, we report on a case of 2 sisters and 1 brother who had familial anterior cervical hypertrichosis without any other abnormality.
Subject(s)
Humans , Cervix Uteri , Hair , Hypertrichosis , Inheritance Patterns , Neck , Pharynx , Retinaldehyde , SiblingsABSTRACT
Sweet's syndrome is a reactive dermatosis characterized clinically by fever, leukocytosis, and multiple, erythematous, painful plaques. Histopathologic examination reveals a band-like dense dermal inflammatory infiltrate composed mainly of neutrophils with papillary dermal edema, and no features of vasculitis. We report a case of a 56-year-old female diagnosed with cervical cancer, who underwent surgery and concurrent chemoradiation therapy. Approximately 3 years after completing treatment, she presented with erythematous plaques, principally within the radiation field; the skin biopsy showed features consistent with Sweet's syndrome.
Subject(s)
Female , Humans , Middle Aged , Biopsy , Edema , Fever , Leukocytosis , Neutrophils , Skin , Skin Diseases , Sweet Syndrome , Uterine Cervical Neoplasms , VasculitisABSTRACT
Eccrine syringofibroadenoma (ESFA) is a rare, benign adnexal neoplasm of eccrine ductal differentiation. It shows variable clinical findings ranging from a solitary papule or nodule to multiple lesions withlinear or diffuse distribution. Typically, it occurs as a solitary nodule on the extremities of elderly people. Histopathologic findings usually show proliferation of anastomosing cords and strands of cuboidal epithelial cells embedded in fibrovascular stroma. We report an uncommon case of solitary eccrine syringofibroadenoma with plasma cell infiltration on the dorsum of the foot of a 53-year-old man.
Subject(s)
Aged , Humans , Middle Aged , Epithelial Cells , Extremities , Foot , Plasma CellsABSTRACT
Eccrine syringofibroadenoma (ESFA) is a rare, benign adnexal neoplasm of eccrine ductal differentiation. It shows variable clinical findings ranging from a solitary papule or nodule to multiple lesions withlinear or diffuse distribution. Typically, it occurs as a solitary nodule on the extremities of elderly people. Histopathologic findings usually show proliferation of anastomosing cords and strands of cuboidal epithelial cells embedded in fibrovascular stroma. We report an uncommon case of solitary eccrine syringofibroadenoma with plasma cell infiltration on the dorsum of the foot of a 53-year-old man.